What invalidating breast cancer gene patents implies


11-Dec-2020 09:05

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In a further aspect, the tumor antigen is (a) the amino acid residues of the 12 times the wild-type Ras protein mutated position contrast, the peptide including at least 8 to 16-position of the Ras protein;본 발명의 또 다른 구체예는 Ras 아미노산 서열 중 73번 위치에서의 프롤린(P73), 74번 위치에서의 트레오닌(T74), 75번 위치에서의 글라이신(G75), 77번 위치에서의 글라이신(G77) 및/또는 78번 위치에서의 페닐알라닌(F78)이 돌연변이된, Ras (H-Ras, N-Ras 또는 K-Ras)를 코딩하는 핵산 서열의 5개 이상의 연속 아미노산을 포함하는 단리된 핵산 분자에 관한 것이다.

Another embodiment of the present invention is glycine in Ras amino acid sequence of the 73 proline (P73) in a position, threonine (T74) at the 74-position, glycine (G75) at the 75-position, 77-position (G77 ) and / or a phenylalanine (F78) at the 78-position mutation, Ras (H-Ras, N-Ras, or a nucleic acid molecule is isolated comprising a continuous amino acid five or more of the nucleic acid sequence encoding a K-Ras) It relates.

And b) the fusion is with respect to the wild-type K-ras, N-ras or H-ras protein contains a mutation Ras protein or a fragment containing the mutated amino acid in position 76 wild-type compared to expression under the control of Cup1 promoter protein It relates to a vaccine comprising a.

In one aspect, the fusion protein to a second mutant Ras protein or a fragment containing an amino acid mutation at position 12 times the wild-type compared to the fusion protein associated with the wild-type K-ras, N-ras or H-ras protein It includes further.

In another embodiment, the present invention is a set of different nucleic acid molecules, i.e., 59 times, 61 times, 73 times, 74 times, 75 times, 76 times, at least one mutation at a position selected from 77 or 78-position one or more containing at least one additional mutation but are not more than one nucleic acid molecule and thereby limit containing (preferably from one to 78 times 73 locations selected from any one of a), including the G12 mutant, and G13 mutant additional nucleic acid It provides a combination of molecules.

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12 position in relation to the H-ras protein containing mutated Ras protein or a fragment thereof; ii) wild-type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid glutamine is the time of the time position 61 substituted with arginine 61 located Ras protein or a fragment thereof; iii) wild type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid number 12 of a glycine in position number 12 is substituted with aspartic acid position Ras protein or a fragment thereof; iv) the wild-type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid number 12 of a glycine in position number 12 is substituted with valine position Ras protein or a fragment thereof; v) the wild-type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid number 12 of a glycine in position number 12 is substituted with arginine position Ras protein or a fragment thereof; vi) the wild-type K-ras, N-ras or H-ras mutation in which the glutamic acid in relation to the protein containing the amino acid at position 76 of the 76-position is substituted with glycine Ras protein or a fragment thereof.Typically, cells and neoplasms formative growth of the organization is characterized by greater than normal growth of cells, these cells grow, even after the encouraging factors (for example, a tumor promoter, carcinogen, virus) that does not exist anymore It continues.